Filip is a member of Petr Svoboda’s Laboratory of epigenetic regulations at Institute of Molecular Genetics in Prague and is at the start of his PhD at Charles University co-supervised by prof. Kristian Vlahoviček. He completed the Molecular Biology study program at the Division of Biology, Faculty of Science, University of Zagreb in 2016.
Filip is studying RNA dynamics during the oocyte-to-embryo transition in mammals in order to characterize the evolution and function of different classes of RNAs and discover novel patterns in their expression and regulation. Beside mRNAs and other long (>200 nt) RNA molecules present in mammalian oocytes, he is investigating roles of small RNAs (21-30 nt) involved in three distinctive pathways mediating sequence-specific silencing of gene expression: RNA interference, microRNA and PIWI-associated RNA pathways. Along with analysing high-throughput sequencing data produced in-house, he is supporting his research by data mining publicly available data sets from NCBI and other online databases.
1. Franke, V., Ganesh, S., Karlic, R., Malik, R., Pasulka, J., Horvat, F., Kuzman, M., Fulka, H., Cernohorska, M., Urbanova, J., et al. Long terminal repeats power evolution of genes and gene expression programs in mammalian oocytes and zygotes.- Genome Res. gr.216150.116. (2017)