PRO-MINE :: Help

Mutations should be in format XposY where:

X is the wild-type amino acid
pos is the position of the substitution in the sequence
Y is the mutant amino acid

e.g., M337V

Enter only one mutation per line, either when using the textbox area or when uploading a file with the mutations:

e.g.,
G125V
F177D

TDP-43 mutations core set refers to all the mutations stored in the PRO-MINE database which represent the most exhaustive and curated up to date status of identified and characterized TDP-43 gene mutations.

If this option is selected, the TDP-43 mutations core set will be analysed in addition to the mutations entered as queries, if any. The predictions for the TDP-43 mutations core set are pre-computed to reduce the waiting time.

To view the list of the TDP-43 core mutations click on the link below:

TARDBP/TDP-43

We plan to expand the PRO-MINE database to cover more genes found to be important in Fronto Temporal Lobar Degeneration (FTLD) and Amyotrophic Lateral Sclerosis (ALS) and eventually other genes encoding disease classes of proteins and their disease-associated mutations.

NetPhos
Predicts phosphorylation sites for all the three amino acids serine, threonine and tyrosine in eukaryotic proteins. [link]

PolyPhen
Predicts possible impact of an amino acid substitution on the structure and function of a human protein using straightforward physical and comparative considerations. [link]

SIFT
Predicts whether an amino acid substitution affects protein function based on sequence homology and the physical properties of amino acids. [link]

SNAP
Predicts the effects of single amino acid substitutions on protein function using in silico derived protein information. [link]

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